Positional Information, Positional Error, and Readout Precision in Morphogenesis: A Mathematical Framework
نویسندگان
چکیده
منابع مشابه
Positional information, positional error, and readout precision in morphogenesis: a mathematical framework.
The concept of positional information is central to our understanding of how cells determine their location in a multicellular structure and thereby their developmental fates. Nevertheless, positional information has neither been defined mathematically nor quantified in a principled way. Here we provide an information-theoretic definition in the context of developmental gene expression patterns...
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Living cells respond to spatially confined signals. Intracellular signal transmission often involves the release of second messengers like Ca. They will eventually trigger a physiological response, for example, by activating kinases that in turn activate target proteins through phosphorylation. Here, we investigate theoretically how positional information can be accurately read out by protein p...
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Objective(s). Main aim of this cross-sectional study was to analyse intra-positional, inter-positional differences in proportions of particular somatotype categories in youth volleyball players. Methods. Heath-Carter method was used to determine somatotype characteristics of 181 young female volleyball players (age 14.05±0.93, height 170.03±7.61 cm, mass 57.80±8.59 kg, bod...
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Cells in a developing embryo have no direct way of "measuring" their physical position. Through a variety of processes, however, the expression levels of multiple genes come to be correlated with position, and these expression levels thus form a code for "positional information." We show how to measure this information, in bits, using the gap genes in the Drosophila embryo as an example. Indivi...
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In many spatial data applications, the events at a location are highly influenced by the events at neighboring locations. In fact, this natural inclination of a variable to exhibit similar values as a function of distance between the spatial locations at which it is being measured is known as spatial dependence. Spatial autocorrelation is used to measure this spatial dependence. If the variable...
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ژورنال
عنوان ژورنال: Genetics
سال: 2014
ISSN: 1943-2631
DOI: 10.1534/genetics.114.171850